Automated cervical digitized histology whole-slide image analysis toolbox

Sudhir Sornapudi; Ravitej Addanki; R Joe Stanley; William V Stoecker; Rodney Long; Rosemary Zuna; Shellaine R Frazier; Sameer Antani

doi:10.4103/jpi.jpi_52_20

ORIGINAL ARTICLE

Year : 2021 | Volume : 12 | Issue : 1 | Page : 26

Automated cervical digitized histology whole-slide image analysis toolbox

Sudhir Sornapudi¹, Ravitej Addanki¹, R Joe Stanley¹, William V Stoecker², Rodney Long³, Rosemary Zuna⁴, Shellaine R Frazier⁵, Sameer Antani³
¹ Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, MO, USA
² Stoecker and Associates, Rolla, MO, USA
³ Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
⁴ Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
⁵ Department of Surgical Pathology, University of Missouri Hospitals and Clinics, Columbia, MO, USA

Correspondence Address:
Dr. R Joe Stanley
127 Emerson Electric Co. Hall, 301 W. 16th St, Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, MO 65409-0040
USA

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jpi.jpi_52_20

Background: Cervical intraepithelial neoplasia (CIN) is regarded as a potential precancerous state of the uterine cervix. Timely and appropriate early treatment of CIN can help reduce cervical cancer mortality. Accurate estimation of CIN grade correlated with human papillomavirus type, which is the primary cause of the disease, helps determine the patient's risk for developing the disease. Colposcopy is used to select women for biopsy. Expert pathologists examine the biopsied cervical epithelial tissue under a microscope. The examination can take a long time and is prone to error and often results in high inter-and intra-observer variability in outcomes. Methodology: We propose a novel image analysis toolbox that can automate CIN diagnosis using whole slide image (digitized biopsies) of cervical tissue samples. The toolbox is built as a four-step deep learning model that detects the epithelium regions, segments the detected epithelial portions, analyzes local vertical segment regions, and finally classifies each epithelium block with localized attention. We propose an epithelium detection network in this study and make use of our earlier research on epithelium segmentation and CIN classification to complete the design of the end-to-end CIN diagnosis toolbox. Results: The results show that automated epithelium detection and segmentation for CIN classification yields comparable results to manually segmented epithelium CIN classification. Conclusion: This highlights the potential as a tool for automated digitized histology slide image analysis to assist expert pathologists.

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